HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyloxycarbonylglycine → 7-(N-benzyloxycarbonylglycyl)-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | 1,4-dithia-7-azaspiro-[4.4]nonane-8(S)-carboxylic acid, ethyl ester | HCID 14515252 | — |
| Reactant | 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro [4.4]nonane-8(S)carboxylic acid, ethyl ester | HCID 14540988 | — |
| Product | 7-(N-benzyloxycarbonylglycyl)-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid, ethyl ester | HCID 13373629 | — |
Reaction Steps
Convert 2.22 g of 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid, ethyl ester (prepared as described in paragraph A) to 1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid, ethyl ester as described in Example 1 and couple this compound with 1.5 g of N-benzyloxycarbonylglycine, N-hydroxysuccinimide ester as described in Example 2 to yield 7-(N-benzyloxycarbonylglycyl)-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid, ethyl ester, a yellow oil [α]D24 -15.9°. (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04470972 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-7bea0a87730d498bb2a91a45c8c2cf59 |
| Source note | uspto-grants-1984_09 |