Ethyl alpha-oxobenzenebutanoate → HCID 13373622, compound

HRID 2417778Notes

Reaction equation

HRID 2417778 reaction equation
Br.[NH2:2][CH2:3][C:4]([N:6]1[C@H:14]([C:15]([OH:17])=[O:16])[CH2:13][C:8]2([S:12][CH2:11][CH2:10][S:9]2)[CH2:7]1)=[O:5].O=[C:19]([CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:20]([O:22][CH2:23][CH3:24])=[O:21]>C(O)C>[C:20]([CH:19]([NH:2][CH2:3][C:4]([N:6]1[C@H:14]([C:15]([OH:17])=[O:16])[CH2:13][C:8]2([S:12][CH2:11][CH2:10][S:9]2)[CH2:7]1)=[O:5])[CH2:25][CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)([O:22][CH2:23][CH3:24])=[O:21]

Participants

4

Reactant 2

HCID 562087Ethyl alpha-oxobenzenebutanoateHCID 13373625HCID 13373625, compound

Product 1

HCID 13373622HCID 13373622, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described in Example 1F, couple 0.76 g of 7-glycyl-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid, hydrobromide (prepared as described in paragraph D next above) with 0.50 g of 2-oxo-4-phenylbutyric acid, ethyl ester to obtain 7-[N-(1-carboethoxy-3-phenylpropyl)glycyl]-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid [α]D26 -39.0° (ethanol).

Sources & evidence

ORD record
ord-07d835ac98f8476a93229a16d4c19417
Source dataset
uspto-grants-1984_09
Patent number
US04470972

Reaction notes

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