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Methane → Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methane | HCID 297 | — |
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | Ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate | HCID 104609 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxylate | HCID 104610 | — |
反応手順
A mixture of 24.7 g of 1-carbethoxy-4-(2-amino-4-chloroanilino)-piperidine and 7.2 g of urea was heated to 160°-180° C. for 3.5 hours. The melt was taken up in 250 ml of toluene and heated, while stirring, until everything had dissolved. The solution was clarified with active charcoal, filtered and concentrated to 50 ml. The product was precipitated with diisopropyl ether. Melting point: 160° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04470989 |
| 出典データセット | uspto-grants-1984_09 |
| ORD ID | ord-ce47b2e418934eda94a0f219f6f3ac23 |
| 出典メモ | uspto-grants-1984_09 |