1,4-Benzodioxane-2-methanol → 2-(Chloromethyl)-2,3-dihydro-1,4-benzodioxin

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Reaction Steps

0.42 mole of 2-hydroxymethyl-1,4-benzodioxane, 0.42 mole of thionyl chloride and 600 ml of dry pyridine were heated at 100° C. for 3 hours. After the mixture had been cooled, ice-cold dilute hydrochloric acid was added and the mixture was extracted with ether. After drying, the solvent was removed and the residue was distilled in vacuo. Boiling point: 80° C. (0.9 mbar).

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