HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chloro-2-nitroanilino)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromomethyl-1,4-benzodioxane | HCID 98333 | — |
| Reactant | 4-(5-Chloro-2-nitroanilino)-piperidine hydrobromide | HCID 20446693 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 3-Methyl-2-butanone | HCID 11251 | — |
| Product | 1-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chloro-2-nitroanilino)-piperidine | HCID 20446711 | — |
Reaction Steps
11.5 g of 2-bromomethyl-1,4-benzodioxane, 20.4 g of 4-(5-chloro-2-nitroanilino)-piperidine hydrobromide, 20 g of potassium carbonate and 0.5 g of potassium iodide were dissolved in 120 ml of methyl isopropyl ketone and the solution was heated under reflux for 24 hours. After the mixture had been cooled, water was added and the organic phase was separated off, dried and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04470989 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-241920d0884c49228990511222590c2c |
| Source note | uspto-grants-1984_09 |