Hydroxylamine → 5-[5-(Hydroxycarbamoyl)pentyl]-imidazo[1,5-a]-pyridine

Participants

Reaction Steps

A solution of hydroxylamine (from 2.06 g of hydroxylamine hydrochloride and 2.02 g of sodium hydroxide) and 5-(5-methoxycarbonylpentyl)imidazo[1,5-a]pyridine (6.08 g) in 25 ml of methanol is allowed to stand at room temperature for 20 hours. The methanol is evaporated and the residue is taken up in 5 ml of water and adjusted to pH=7. The resulting oil crystallizes and the solid is collected, yielding 5-[5-(hydroxycarbamoyl)pentyl]-imidazo[1,5-a]-pyridine, m.p. 138°-140°.

Provenance & Evidence