HCID 13338728, compound → HCID 13338729, compound

HRID 2417845Notes

Reaction equation

HRID 2417845 reaction equation
C(O[CH:5]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[NH:11][C:10](=[O:18])[CH2:9][CH2:8][CH2:7][CH2:6]1)(=O)C>C(O)C.[Pd]>[NH:11]1[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1=[O:18]

Participants

4

Reactant 1

HCID 13338728HCID 13338728, compound

Product 1

HCID 13338729HCID 13338729, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 7-acetoxy-1,3,4,5,6,7-hexahydro-1-benzazonin-2-one (7.4 g) in ethanol (250 ml) is hydrogenated at 45 psi at 70° C. using 10% palladium on charcoal (1.5 g) as catalyst. The catalyst is filtered off and the solvent removed under reduced pressure. The residue is recrystallized to give 1,3,4,5,6,7-hexahydro-1-benzazonin-2-one.

Workup

  1. customis hydrogenated at 45 psi at 70° C.
  2. filtrationThe catalyst is filtered off
  3. customthe solvent removed under reduced pressure
  4. customThe residue is recrystallized

Sources & evidence

ORD record
ord-34272d586a484d918764ff9e8a95de6b
Source dataset
uspto-grants-1984_09
Patent number
US04470988

Reaction notes

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