Acetic Anhydride → HCID 20269005, compound

HRID 2417851Notes

Reaction equation

HRID 2417851 reaction equation
[OH:1][CH:2]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6](=[O:14])[CH2:5][CH2:4][CH2:3]1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[C:15]([O:1][CH:2]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6](=[O:14])[CH2:5][CH2:4][CH2:3]1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 20269010HCID 20269010, compound

Product 1

HCID 20269005HCID 20269005, compound

Procedure

A solution of 6-hydroxy-3,4,5,6-tetrahydro-1-benzazocin-2-(1H)one (9.2 g) in acetic anhydride (200 ml) is maintained at 80° C. for 3 hours. The reaction mixture is cooled to room temperature and the solvents removed under reduced pressure. Ether (300 ml) is added, and their resulting solution washed with water (150 ml) and dried over magnesium sulfate. The solvent is removed under reduced pressure to give 6-acetoxy-3,4,5,6-tetrahydro-1-benzazocin-2(1H)-one.

Workup

  1. customthe solvents removed under reduced pressure
  2. additionEther (300 ml) is added
  3. customtheir resulting solution
  4. washwashed with water (150 ml)
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-4d58a634ffca4eb583c91d2dbaa4c7f9
Source dataset
uspto-grants-1984_09
Patent number
US04470988

Reaction notes

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