HCID 13384939, compound → HCID 53814890, compound

Participants

Reaction Steps

A solution of 1.6 g of 2-carboxyphenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-1-thio-β-D-glucopyranoside in 15 ml of a mixture of 2N triethylamine:methanol:water (3:6:2) was stirred for 16 hours, then concentrated in vacuo to a solid. This solid was dissolved in water, adjusted to pH 3.5, diluted further with water producing a slurry which was applied to 150 ml of a polystyrene resin, for example, Amberlite® XAD-2 resin (Norman Haase) and then eluted with 500 ml of water followed by one liter of 80% methanol. The methanol eluate give 0.6 g of the desired intermediate as a solid.

Provenance & Evidence