Carbon Dioxide → HCID 20280999, compound

Participants

Reaction Steps

A solution of bromine (4.2 g.) in chloroform (20 ml.) was added dropwise to a cooled stirred solution of 3'-valeryloxymethyl-4'-valeryloxyacetophenone (8.5 g.) in chloroform (100 ml.). During the addition, the temperature was maintained at 0°-5° C. by the addition of small pieces of solid carbon dioxide. The solution was then washed with 10% w/v sodium carbonate solution (3×100 ml.) water (2×100 ml.) and saturated brine (100 ml.). The organic phase was dried (MgSO4), filtered, and evaporated yielding 3'-valeryloxymethyl-4'-valeryloxy-2-bromoacetophenone (6 g., 57%), which was judged to be sufficiently pure by IR and TLC [SiO2 : 50 v/v EtOAc/petrol (60°-80°)] for use without further purification or characterisation.

Provenance & Evidence