HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → (4-Chloro-3-isothiocyanatophenyl)phenylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 3-amino-4-chlorobenzophenone | HCID 10799548 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (4-Chloro-3-isothiocyanatophenyl)phenylmethanone | HCID 12874009 | 85% |
Reaction Steps
A mixture of 17 parts of (3-amino-4-chlorophenyl)phenylmethanone, 9.5 parts of carbonothioic dichloride and 200 parts of 1,4-dioxane is stirred and refluxed for 15 minutes. The reaction mixture is evaporated and the oily residue is crystallized from 2,2'-oxybispropane. The product is filtered off and dried, yielding 17 parts (85%) of (4-chloro-3-isothiocyanatophenyl)phenylmethanone; mp. 96.7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04471117 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-2a0e2429f3684655945b95fd2ee4ff60 |
| Source note | uspto-grants-1984_09 |