Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 13338500 | HCID 13338500 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 13338527 | HCID 13338527 | — |
Reaction Steps
A mixture of 14 parts of N-(5-benzoyl-2-chlorophenyl)-N'-(3-hydroxypropyl)thiourea, 5 parts of sodium hydride dispersion 75% and 180 parts of N,N-dimethylacetamide is stirred and heated quickly to 130° C. The reaction mixture is cooled and poured onto water. The precipitated product is filtered off and crystallized from ethanol, yielding 1.8 parts of {2-[(3-hydroxypropyl)amino]-5-benzothiazolyl}phenylmethanone; mp. 162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04471117 |
|---|
| Source dataset | uspto-grants-1984_09 |
|---|
| ORD ID | ord-1f7409f0f0574209826af211a79ba4c9 |
|---|
| Source note | uspto-grants-1984_09 |
|---|
