Carbon Tetrachloride → HCID 20446964, compound

Participants

Reaction Steps

To a stirred mixture of 27.7 parts of N-(3-hydroxypropyl)-N'-(3-propylphenyl)thiourea and 240 parts of tetrachloromethane are added 17.6 parts of bromine and the whole is stirred and refluxed for 1 hours. About 80 parts of acetonitrile are added and the formed hydrobromide salt is allowed to crystallize. It is filtered off, washed with acetonitrile and dissolved in water. The free base is liberated in the conventional manner with ammonium hydroxide and extracted with 1,1'-oxybisethane. The extract is dried, filtered and evaporated, yielding 18 parts of 3-(5-propyl-2-benzothiazolylamino)-1-propanol as an oily residue.

Provenance & Evidence