Trifluoroacetic acid → HCID 13338630, compound

Participants

Reaction Steps

To a stirred mixture of 45 parts of trifluoroacetic acid and 2 parts of 3,4-dihydro-2H-pyrimido[2,1-b]benzothiazol-7-amine are added portionwise, during a 4 hours-period, 3 parts of sodium borohydride at 30°-40° C. while nitrogen gas is introduced. The reaction mixture is poured onto ice-water and the whole is alkalized with ammonium hydroxide. The product is extracted with methylbenzene. The extract is washed with water, dried, filtered and evaporated. The residue is crystallized from 8 parts of acetonitrile, yielding 0.55 parts of 3,4-dihydro-N-(2,2,2-trifluoroethyl)-2H-pyrimido[2,1-b]benzothiazol-7-amine; mp. 186.7° C.

Provenance & Evidence