Acetic Anhydride → HCID 13338631, compound

Participants

Reaction Steps

To 25 parts of acetic acid anhydride are added portionwise 1.3 parts of 3,4-dihydro-2H-pyrimido[2,1-b]benzothiazol-7-amine (exothermic reaction: temp. rises to 30° C.). Upon completion, stirring is continued for one hour at room temperature. After cooling to 5°-10° C., the precipitated product is filtered off and dissolved in water. The solution is treated with activated charcoal. The latter is filtered off over hyflo and the filtrate is alkalized with a few drops of ammonium hydroxide. Upon stirring, the product is allowed to crystallize. It is filtered off and dried, yielding 0.8 parts of N-(3,4-dihydro-2H-pyrimido[2,1-b]benzothiazol-7-yl)acetamide; mp. 178° C.

Provenance & Evidence