3,4,5-Trimethoxybenzaldehyde → HCID 13338633, compound

Participants

Reaction Steps

To a stirred mixture of 6.2 parts of 3,4-dihydro-2H-pyrimido[2,1-b]benzothiazol-7-amine, 7.8 parts of 3,4,5-trimethoxybenzaldehyde and 60 parts of acetic acid are added portionwise 1.2 parts of sodium borohydride at a temperature between 18° and 20° C. Upon completion, stirring is continued for 30 minutes at room temperature. Water is added and the whole is alkalized with ammonium hydroxide. The product is extracted with trichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from ethanol, yielding 9.2 parts of 3,4-dihydro-N-(3,4,5-trimethoxyphenylmethyl)-2H-pyrimido[2,1-b]benzothiazol-7-amine; mp. 190.7° C.

Provenance & Evidence