HRID2417928

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID77703

p-Toluenesulphonyl isocyanate

C8H7NO3S

结构：CCCc1c2[nH]c(C(=O)OC)cc(=O)c2cc2c(=O)cc(C(=O)OCC)oc12

HCID13101142

未命名化合物

PRODUCTS

生成物

结构：CCCc1c2nc(C(=O)OC)cc(NS(=O)(=O)c3ccc(C)cc3)c2cc2c(=O)cc(C(=O)OCC)oc12

HCID13352258

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6365

1,1-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

Ethyl 6,9-dihydro-4,6-dioxo-8-methoxycarbonyl-10-propyl-4Hpyrano[3,2-g]quinoline-2-carboxylate (38.5 g, 0.1 mol) was suspended in dichloroethane (200 ml) and 4-toluene-sulphonyl isocyanate (15.1 ml; 0.1 mol) added at room temperature. The whole was then refluxed for 16 hours, allowed to cool, and filtered, to give the sub-title compound as brillant yellow cubes, 44.0 g (82%), m.p. 219° C.

WORKUP

后处理

temperatureThe whole was then refluxed for 16 hours
temperatureto cool
filtrationfiltered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1f9e41e2dd44a929a54b3d9c53f4c28
来源数据集: uspto-grants-1984_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04471119
来源说明: uspto-grants-1984_09

反应 SMILES

[O:1]=[C:2]1[C:7]2[CH:8]=[C:9]3[C:14](=[C:15]([CH2:16][CH2:17][CH3:18])[C:6]=2[O:5][C:4]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:3]1)[NH:13][C:12]([C:19]([O:21][CH3:22])=[O:20])=[CH:11][C:10]3=O.[C:29]1([CH3:41])[CH:34]=[CH:33][C:32]([S:35]([N:38]=C=O)(=[O:37])=[O:36])=[CH:31][CH:30]=1>ClC(Cl)C>[CH3:22][O:21][C:19]([C:12]1[CH:11]=[C:10]([NH:38][S:35]([C:32]2[CH:33]=[CH:34][C:29]([CH3:41])=[CH:30][CH:31]=2)(=[O:36])=[O:37])[C:9]2[C:14](=[C:15]([CH2:16][CH2:17][CH3:18])[C:6]3[O:5][C:4]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:3][C:2](=[O:1])[C:7]=3[CH:8]=2)[N:13]=1)=[O:20]