HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 13338455, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Chloro-10-[3-[4-(2-chloroethyl)piperazin-1-yl]propyl]phenothiazine | HCID 5275455 | — |
| Reactant | 4-[5-(1-Methylethyl)aminopentoxy]phenol | HCID 13338488 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13338455 | HCID 13338455 | 145.4% |
Reaction Steps
A solution of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-(2-chloroethyl)piperazine (9.2 g) and 4-[5-(1-methylethyl)aminopentoxy]phenol (5.16 g) in 150 ml dimethylsulfoxide was treated with sodium hydroxide (0.87 g) in water (7 ml) and was stirred at 55°-60° for 5 hours. The usual work-up furnished the crude trihydrochloride salt which was recrystallized from methanol to give 5.8 g of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[5-(1-methylethyl)aminopentoxy]phenoxy]ethyl]piperazine trihydrochloride, mp 237°-239°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04471116 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-3b8eed28d3314fcebd3f66052729777b |
| Source note | uspto-grants-1984_09 |