Sodium Hydroxide → 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[4-(1-methylethyl)aminobutyl]phenoxy]ethyl]piperazine trihydrochloride

Participants

Reaction Steps

A solution of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-(2-chloroethyl)piperazine (10 g) and 4-[4-(1-methylethyl)aminobutyl]phenol (4.9 g) was stirred at 55° under nitrogen and a solution of sodium hydroxide (0.94 g) in water (7 ml) was added. The reaction was stirred and heated at 55°-65° for 5 hours. The usual work-up yielded the crude trihydrochloride salt. Crystallization of the product from methanol-ethanol yielded 5.3 g of 1-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-4-[2-[4-[4-(1-methylethyl)aminobutyl]phenoxy]ethyl]piperazine trihydrochloride, mp 245°-248°.

Provenance & Evidence