HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cysteamine Hydrochloride → 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cysteamine Hydrochloride | HCID 9082 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-((Dimethylamino)methyl)thiazol-4-yl)methanol | HCID 1838020 | — |
| Reactant | N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine | HCID 1967272 | — |
| Product | 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole | HCID 10977318 | — |
Reaction Steps
When 2-dimethylaminomethyl-4-hydroxymethylthiazole [prepared in Step D] is reacted with thionyl chloride and the resultant 2-dimethylaminomethyl-4-chloromethylthiazole is reacted with an equimolar amount of cysteamine hydrochloride and two equivalents of base according to the general procedure of Example 33, Step D, the title compound is thereby produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04471122 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-7e6b26a1efb0431bb4cb1f222c6fcd40 |
| Source note | uspto-grants-1984_09 |