反应详情

The hydrazone (28) (500 mg) was dissolved in dichlorobenzene and heated to reflux in a sealed tube for 4 hours. The reaction was allowed to cool and cyclohexane was added dropwise to crystallize the desired product. Filtration and drying in vacuo yielded the desired dihydropyridazine ester (29) (295 mg) as a solid. MS+: m/e=307.0 (M+H).

1. temperatureheated
2. temperatureto reflux in a sealed tube for 4 hours
3. temperatureto cool
4. customto crystallize the desired product
5. filtrationFiltration
6. customdrying in vacuo