Hydrochloric Acid → HCID 46187154, compound

Participants

Reaction Steps

An aqueous solution of HCl (4 N, 2 mL) was added to a stirred solution of 19 (134 mg, 0.29 mmol) in THF (2 mL) at room temperature. The resulting mixture was stirred at room temperature for overnight. The solvent was removed under reduced pressure and the residue was treated with Et2O (2 mL). The precipitate was collected by filtration and washed with dichloromethane to give a white solid (63 mg, 55%): 1H NMR (400 MHz, DMSO-d6) δ 10.66 (s, 1H), 8.17 (s, 1H), 7.97 (d, J=8.4 Hz, 1H), 7.89 (brs, 3H), 7.88 (d, J=8.0 Hz, 1H), 7.80 (d, J=8.0 Hz, 2H), 7.56 (t, J=7.2 Hz, 1H), 7.50 (s, 1H), 7.43 (t, J=6.8 Hz, 1H), 7.43 (d, J=8.8 Hz, 2H), 4.29 (t, J=5.6 Hz, 2H), 2.95-3.03 (m, 2H), 2.10 (quintet, J=6.4 Hz, 2H); 13C NMR (100 MHz, DMSO-d6) δ 165.1. 152.9, 138.0, 134.8, 129.5, 128.7, 128.2, 127.8, 127.5, 127.2, 127.1, 126.5, 124.5, 121.2, 107.2, 65.5, 36.6, 26.5.

Provenance & Evidence