HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 70507076, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 17beta-Acetoxy-3beta-benzoyloxy-7alpha-chloro-5,6beta-epoxy-15beta,16beta-methylene-5beta-androstane | HCID 88717469 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 70507076 | HCID 70507076 | 72.5% |
Reaction Steps
200 mg of 17β-acetoxy-3β-benzoyloxy-7α-chloro-5,6β-epoxy-15β,16β-methylene-5β-androstane is stirred in 4 ml of acetic acid and 4 ml of propan-2-ol with 800 mg of zinc dust for 1 hour at 80° C. The mixture is filtered off from the zinc, washed with diethyl ether, and worked up analogously to Example 1. After chromatography and recrystallization from diisopropyl ether-acetone, 135 mg of 17β-acetoxy-3β-benzoyloxy-15β,16β-methylene-5β-androst-6-en-5-ol is obtained, mp 212°-212.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472310 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-c2fbf1e1d3e34f6c993686c285a81754 |
| Source note | uspto-grants-1984_09 |