反应详情

1-Methoxalyl-3-benzyloxycarbonylamino-2-azetidinone (240 mg.) was dissolved in methanol (10 ml.), and sodium methylate (6 mg.) was added to said solution, and then the mixture was heated under reflux for 45 minutes. The methanol was distilled off from the reaction mixture, and the residue was washed with ether to give crude 3-benzyloxycarbonylamino-2-azetidinone (126 mg.). Furthermore, this product was recrystallized from acetone to give the purified compound (50 mg.). And, the purified same compound (54 mg.) was recovered from the mother liquor. Total yield was 104 mg. Mp 164° to 165° C.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 45 minutes
3. distillationThe methanol was distilled off from the reaction mixture
4. washthe residue was washed with ether