Dichloromethane → HCID 15583178, compound

Participants

Reaction Steps

181 g of 3-n-propylquinazoline-2,4-(1H,3H)-dione (0.887 mole) in 1200 ml of phosphorus oxychloride was refluxed for two days when TLC (SiO2, CH2Cl2 /2% MeOH) indicated that most of the starting material had gone. TLC was carried out by pipetting a small portion of the reaction mixture into ice-water, allowing the hydrolysis of POCl3 to occur at 0° C. for 15 min. and then extracting the cold solution with chloroform. The TLC plate when run might be expected to show a small amount of starting dione derived from hydrolysis of the imino chloride during the work up-TLC procedure.

Provenance & Evidence