Dichloromethane → HCID 15583179, compound

Participants

Reaction Steps

The crude solid imino chloride of Step C was dissolved in 800 ml of ethanol and 400 ml of hydrazine hydrate and the mixture was refluxed for two hours until TLC indicated (SiO2, CH2Cl2 /2% MeOH) that no imino chloride remained. 500 ml of water were added to the mixture and the mixture was cooled inducing a crystalline precipitate of the product. The precipitation was filtered, washed well with water, then dried over P2O5 under vacuum to obtain 158 g (82% yield) of 2-hydrazino-3-n-propylquinazolin-4(3H)-one in the form of a pale yellow solid melting at 125°-8° C.

Provenance & Evidence