HCID 15583218, compound → HCID 20446033, compound

HRID 2418214Notes

Reaction equation

HRID 2418214 reaction equation
[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]2[C:15]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[N:16][N:17]=[C:5]12)[CH:2]=[CH2:3].[H][H].C(Cl)(Cl)[Cl:28].C(O)C>>[OH2:14].[ClH:28].[N:19]1([CH2:18][C:15]2[N:6]3[C:7]4[C:12]([C:13](=[O:14])[N:4]([CH2:1][CH2:2][CH3:3])[C:5]3=[N:17][N:16]=2)=[CH:11][CH:10]=[CH:9][CH:8]=4)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

4

Reactant 3

HCID 15583218HCID 15583218, compoundHCID 21889567Chloroform ethanolHCID 178418361HCID 178418361, compound

Product 1

HCID 20446033HCID 20446033, compound

Procedure

5.0 g of 4-allyl-1-piperidinomethyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one, prepared as described in Example 33, were suspended in 300 ml of a 1-1 chloroform-ethanol mixture and 500 mg of 5% palladized carbon were added thereto. The resultant mixture was hydrogenated at room temperature for 1.5 hours until the calculated amount of hydrogen had been absorbed and the mixture was filtered. The filtrate was evaporated to dryness to obtain 4.3 g of the free base as a colorless solid. The free base was converted into the hydrochloride salt, monohydrate analagously to Example 1. The product thus obtained was identical with respect to melting point, IR and NMR to the product obtained in Example 1.

Workup

  1. additionwere added
  2. customhad been absorbed
  3. filtrationthe mixture was filtered
  4. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-b163190c80fd44209234ba3f5c59f151
Source dataset
uspto-grants-1984_09
Patent number
US04472400

Reaction notes

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