HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-Methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 5-Hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester | HCID 57990210 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester | HCID 57990212 | — |
Reaction Conditions
| Temperature | 5 °C |
|---|
Reaction Steps
To a cooled solution (5° C.) of 5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester (11 Kg, 38.8 mol, step 7) and Et3N (7.04 L, 50.6 mol) in DCM (55 L) was added methanesulphonyl chloride (2.97 L, 38.4 mol) so that the internal temp <10° C. After stirring for 0.5 h at 5° C. the solution was used below in step 9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653084B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-69e29cd167b642779b24af3ed612a99b |
| Source note | uspto-grants-2014_02 |