Sodium Hydroxide → HCID 23720649, compound

HRID 2418232Notes

Reaction equation

HRID 2418232 reaction equation
[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([OH:18])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:19])[CH2:6][CH2:5][C:4]=3[C:3]=1[N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1.[OH-].[Na+:26]>O>[OH2:15].[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([O-:18])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:19])[CH2:6][CH2:5][C:4]=3[C:3]=1[N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1.[Na+:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 736409-Fluoro-8-(1H-imidazol-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid

Product 1

HCID 23720649HCID 23720649, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 0.500 g (1.53 mmole) of 6,7-dihydro-9-fluoro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid (from Example 1) and 10 ml of water was added 15.3 ml of 0.1 N aqueous sodium hydroxide (1.53 mmole). The mixture was filtered, an equal volume of ethanol added, and the solution evaporated to dryness to give tan crystals of sodium 6,7-dihydro-9-fluoro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylate hydrate, m.p.>250° C.

Workup

  1. filtrationThe mixture was filtered
  2. additionan equal volume of ethanol added
  3. customthe solution evaporated to dryness

Sources & evidence

ORD record
ord-91e4987cab934acebd4465406a60cc1b
Source dataset
uspto-grants-1984_09
Patent number
US04472406

Reaction notes

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