Ammonium Hydroxide → HCID 13338836, compound

Participants

Reaction Steps

A mixture of 30 g (0.115 mmole) of 6-fluoro-2-methyl-5-(2-mercaptoimidazol-1-yl)quinoline, 60 ml of ammonium hydroxide and 300 ml of 60% aqueous ethanol was heated to 50°-55° C. and 201 g of Raney nickel was added. The mixture was heated to reflux and maintained at reflux for four hours, at which time it was filtered. The residue was washed with hot aqueous ethanol, and the washings and filtrate were combined and evaporated to provide 6-fluoro-5-(imidazol-1-yl)-2-methylquinoline as a yellow solid.

Provenance & Evidence