HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-Bromo-6-fluoro-2-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 6-Fluoro-2-methylquinoline | HCID 70784 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 5-Bromo-6-fluoro-2-methylquinoline | HCID 13035313 | — |
Reaction Steps
In step (1) of the reaction scheme, the known compound 6-fluoroquinaldine of Formula II is brominated with liquid bromine in the presence of aluminum chloride in a suitable solvent such as 1,2-dichoroethane. The reaction mixture is heated at reflux for several hours to provide the novel intermediate 5-bromo-6-fluoroquinaldine of Formula III.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472407 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-8ffaacac112b42efb986960e135a54ec |
| Source note | uspto-grants-1984_09 |