HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1H-Benzimidazole, 2-(methylthio)-6-(trifluoromethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | HCID 178506086 | HCID 178506086 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1H-Benzimidazole, 2-(methylthio)-6-(trifluoromethyl)- | HCID 20446057 | 82% |
Reaction Steps
A suspension of 20.0 g (0.092 mole) of 5-trifluoromethyl-2-mercaptobenzimidazole and 13.1 g (0.092 mole) of methyl iodide in 200 ml of ethanol is heated to the boil for three hours. The solvent is stripped off in vacuo and the residue is recrystallized from acetonitrile. 17.5 g (82%) of 5-trifluoromethyl-2-methylthio-benzimidazole of m.p. 145°-146° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04472409 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-97133253c5c3462fb51c3012f662c314 |
| Source note | uspto-grants-1984_09 |