反应详情

0.7 g of sodium acetate was added to 7.5 g of 2-chloropropanol, to which 7.4 g of diketene was added dropwise with stirring while the reaction temperature was maintained at 40°-50° C. The reaction mixture was stirred at room temperature for an additional 2 hours and then worked up in the manner described in Referential Example 4. The resulting crude product was purified by distillation to obtain 9.8 g of 2-chloropropyl acetoacetate.

1. additionwas added dropwise
2. temperaturewas maintained at 40°-50° C
3. stirringThe reaction mixture was stirred at room temperature for an additional 2 hours
4. distillationThe resulting crude product was purified by distillation