Ammonia → 2,6-Dimethyl-3,5-dicarboxy-4-(2-nitrophenyl)-1,4-dihydropyridine

Participants

Reaction Steps

In 30 ml of isopropyl alcohol were dissolved 2 g of 3-nitratopropyl acetoacetate and 0.74 g of 2-nitrobenzaldehyde. To the solution was added 4 ml of isopropyl alcohol saturated with an ammonia gas at 10° C. The mixture was treated in the manner described in Example 1 to obtain a residue, which was then subjected to column chromatography on silica gel (eluted with n-hexane-acetone=5:3) and recrystallized from ether to obtain 1.11 g of 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid bis(3-nitratopropyl) ester.

Provenance & Evidence