反应详情

342 g of heptanal were added dropwise to a solution of 525 g of 2,4-dichlorobenzaldehyde and 12 g of NaOH in 1.5 l of methanol in the course of 6 hours. The mixture was allowed to continue reacting for 1 hour, then acidified with glacial acetic acid, and concentrated after a further 15 hours. The residue was taken up in CH2Cl2 /H2O, and the organic phase was washed with water, dried over Na2SO4 and concentrated. Distillation of the residue gave 498 g of (I) of boiling point 152°-160° C./0.2 mbar.

1. concentrationconcentrated after a further 15 hours
2. washthe organic phase was washed with water
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. distillationDistillation of the residue