Hydrochloric Acid → HCID 13141992, compound

Participants

Reaction Steps

168.4 g of 3-(4-acetylphenyl)-2-methylpropyl chloride in 100 ml of diethyl ether were added dropwise to a Grignard suspension prepared from 182.5 g of 4-tert.-butylbenzyl chloride and 26 g of Mg in 400 ml of diethyl ether. After completion of the dropwise addition, the mixture was refluxed for a further 2 hours and then hydrolyzed by adding ice-cooled dilute aqueous HCl until the pH was 2. The organic products were extracted with ether, and the organic phase was washed with water, dried over Na2SO4 and concentrated. Distillation of the residue gave 163.4 g of (VI) of boiling point 190° C./0.1 mbar.

Provenance & Evidence