Bromine → 2-Bromo-1-(4-chlorophenyl)hexan-1-one

HRID 2418285Notes

Reaction equation

HRID 2418285 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:6][CH:5]=1>C(OCC)C>[Br:1][CH:11]([CH2:12][CH2:13][CH2:14][CH3:15])[C:10]([C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:9][CH:8]=1)=[O:16]

Participants

4

Reactant 2

HCID 24408BromineHCID 4581871-(4-chlorophenyl)hexan-1-one

Product 1

HCID 198611492-Bromo-1-(4-chlorophenyl)hexan-1-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Bromine (0.02 mol) was added dropwise to a stirred solution of 4'-chlorohexanophenone (0.02 mol) in dry diethyl ether (20 ml) at 10°-20° over one hour. The ether was then removed in vacuo from the reaction mixture to leave a pale-yellow liquid which on distillation gave 2-bromo-4'-chlorohexanophenone, b.p. 124°-126°/0.04 mm Hg.

Workup

  1. customThe ether was then removed in vacuo from the reaction mixture
  2. customto leave a pale-yellow liquid which
  3. distillationon distillation

Sources & evidence

ORD record
ord-71e95f23b9ac4bf3be344922869998f9
Source dataset
uspto-grants-1984_09
Patent number
US04472415

Reaction notes

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