Hydrochloric Acid → HCID 22827701, compound

Participants

Reaction Steps

A solution of 5.4 g (0.1 mol) sodium methanolate in 50 ml dry methanol is slowly added to a mixture of 62.6 g (0.2 mol) N-(acetoxyacetyl)-N-(2,4-dimethylthien-3-yl)-alanine methylester (=Ex. 3.5) in 750 ml dry methanol with stirring. The mixture is stirred for two hours at room temperature, then freed of solvent in vacuo. The residue is poured into water and the pH adjusted to pH 2 with 2 N aqueous HCl. The product is extracted with CHCl3, the organic phase washed with water, dried over Na2SO4, and evaporated in vacuo to yield the title compound, m.p. 69°-70°.

Provenance & Evidence