HCID 56998903, compound → HCID 135703738, compound

HRID 2418308Notes

Reaction equation

HRID 2418308 reaction equation
[CH3:1][CH:2]1[N:15]2[C:6](=[N:7][C:8]3[CH2:9][CH2:10][CH2:11][CH2:12][C:13]=3[C:14]2=[O:16])[C:5](=[N:17]NC2C=CC=CC=2)[CH2:4][CH2:3]1>O>[CH3:1][CH:2]1[N:15]2[C:6](=[N:7][C:8]3[CH2:9][CH2:10][CH2:11][CH2:12][C:13]=3[C:14]2=[O:16])[C:5]2[NH:17][C:8]3[C:9]([C:4]=2[CH2:3]1)=[CH:10][CH:11]=[CH:12][CH:13]=3

Participants

3

Reactant 1

HCID 56998903HCID 56998903, compound

Product 1

HCID 135703738HCID 135703738, compoundYield 84.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
170 °C

Procedure

1 g of 9-methyl-6-phenylhydrazono-1,2,3,4,6,7,8,9-octahydro-pyrido[2,1-b]quinazoline-11-one is added to 15 g of polyphosphoric acid heated to 170° C. and the mixture is stirred for 20 minutes at 180° C. After cooling, the dark melt is diluted with 50 ml of water. Greenish-yellow crystals are precipitated, which are filtered and washed with water. After drying, the product is recrystallized from ethanol. 0.4 g of 7-methyl-5-oxo-1,2,3,4,7,8-hexahydro-5H,13H-indolo[2',3';3,4]pyrido[2,1-b]quinazoline are obtained melting at 232° C.

Workup

  1. temperatureAfter cooling
  2. customGreenish-yellow crystals are precipitated
  3. filtrationwhich are filtered
  4. washwashed with water
  5. customAfter drying
  6. customthe product is recrystallized from ethanol

Sources & evidence

ORD record
ord-38a6da56b6134c0f8c40d9efb87272ca
Source dataset
uspto-grants-1984_09
Patent number
US04472399

Reaction notes

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