HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2418323Generated: October 26, 2026
Hydrochloric Acid → 2-[2-Nitro-3-(2-fluorophenoxy)phenyl]acetic acid
https://huagongshe.com/reaction/2418323
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Fluorophenol | HCID 9707 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 2-(3-chloro-2-nitrophenyl)acetate | HCID 20446267 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[2-Nitro-3-(2-fluorophenoxy)phenyl]acetic acid | HCID 20446188 | — |
Reaction Steps
A mixture of ethyl 2-(2-nitro-3-chlorophenyl)acetate (10 g.), 2-fluorophenol (5.8 g.), anhydrous potassium carbonate (8.5 g.) and cupric oxide (1 g.) was stirred for 5 hours at 130° C. To the reaction mixture was added conc. hydrochloric acid and water, and the mixture was extracted with benzene. The extract was washed with water, dried over magnesium sulfate and then evaporated under reduced pressure to give oily 2-[2-nitro-3-(2-fluorophenoxy)phenyl]acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04472433 |
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| Source dataset | uspto-grants-1984_09 |
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| ORD ID | ord-b58ecbaccc6d4a70a090ee42d416affc |
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| Source note | uspto-grants-1984_09 |
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