Water → HCID 20446156, compound

HRID 2418349Notes

Reaction equation

HRID 2418349 reaction equation
[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=2[Cl:16])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([O:20]CC)=[O:19].[OH-].[Na+].O>C1C=CC=CC=1>[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=2[Cl:16])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=[O:19]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 20446236Ethyl 2-[2-amino-3-(2,3-dichlorophenoxy)phenyl]acetate

Product 1

HCID 20446156HCID 20446156, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of ethyl 2-[2-amino-3-(2,3-dichlorophenoxy)phenyl]acetate (3.7 g.), sodium hydroxide (880 mg.) and water (50 ml.) was treated in a similar manner to that of Example 5-(2). The resultant residue was pulverized with benzene, and the precipitates were collected by filtration and dried to give 2-[2-amino-3-(2,3-dichlorophenoxy)phenyl]acetic acid (2.65 g.).

Workup

  1. additionwas treated in a similar manner to that of Example 5-(2)
  2. filtrationthe precipitates were collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-27cd226cd5054f90a6f8c1277ba9034d
Source dataset
uspto-grants-1984_09
Patent number
US04472433

Reaction notes

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