Water → HCID 20446144, compound

Participants

Reaction Steps

A mixture of ethyl 2-[2-amino-3-(o-tolyloxy)phenyl]acetate (3.1 g.), sodium hydroxide (0.9 g.), water (20 ml.) and dioxane (20 ml.) was treated in a similar manner to that of Example 2-(2) to give crystals of 2-[2-amino-3-(o-tolyloxy)phenyl]acetic acid (2.0 g.). Thus obtained compound was dissolved in a solution of sodium bicarbonate (0.343 g.) in water (50 ml.) under heating and filtered. The filtrate was lyophilized to give sodium 2-[2-amino-3-(o-tolyloxy)phenyl]acetate (1.1 g.). mp >150° C.

Provenance & Evidence