Sodium Hydroxide → HCID 20446185, compound

HRID 2418352Notes

Reaction equation

HRID 2418352 reaction equation
[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([O:20]CC)=[O:19].[OH-].[Na+]>O>[NH2:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20446259HCID 20446259, compound

Product 1

HCID 20446185HCID 20446185, compoundYield 72.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of ethyl 2-[2-amino-3-(3,4-dimethylphenoxy)phenyl]acetate (3.2 g.), sodium hydroxide (0.9 g.) and water (50 ml.) was treated in a similar manner to that of Example 5-(2). The resultant residue was crystallized with a mixture of benzene and n-hexane to give 2-[2-amino-3-(3,4-dimethylphenoxy)phenyl]acetic acid (2.1 g.). mp 90° to 92° C.

Workup

  1. additionwas treated in a similar manner to that of Example 5-(2)
  2. customThe resultant residue was crystallized with a mixture of benzene and n-hexane

Sources & evidence

ORD record
ord-348af917630e4b57b833cd2a0c258520
Source dataset
uspto-grants-1984_09
Patent number
US04472433

Reaction notes

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