Water → N,N-diethyl-2-[2-amino-3-(2-fluorophenoxy)phenyl]acetamide

Participants

Reaction Steps

A mixture of iron powder (5 g.), ammonium chloride (0.5 g.), ethanol (40 ml.) and water (20 ml.) and a solution of N,N-diethyl-2-[2-nitro-3-(2-fluorophenoxy)phenyl]acetamide (5.1 g.) in ethanol (5 ml.) were treated in a similar manner to that of Example 1-(1) [extraction solvent: ethyl acetate] to give oily N,N-diethyl-2-[2-amino-3-(2-fluorophenoxy)phenyl]acetamide (4.6 g.). This substance was dissolved in a mixture of methanol and hydrochloric acid. The solution was evaporated and the residue was pulverized with ethyl acetate. The resultant product (4.15 g.). was recrystallized from a mixture of ethanol and ethyl acetate to give white needles of the captioned compound (2.95 g.). mp 159° to 160° C.

Provenance & Evidence