Water → HCID 23706966, compound

Participants

Reaction Steps

A mixture of 2-oxo-7-(2,6-dichlorophenoxy)indoline (3.4 g.), sodium hydroxide (1.86 g.) and water (50 ml.) was refluxed under heating for 120 hours with stirring. Insoluble starting material (2.5 g.) was recovered by filtration and the filtrate was cooled. The precipitates were collected by filtration and washed with a small amount of water and diethyl ether in turn to give the captioned compound (1.35 g.). Further, to the above obtained insoluble material (2.5 g.) were added sodium hydroxide (2 g.) and 50% dioxane (50 ml.), and the mixture was stirred for 70 hours and filtered. After cooling, the precipitates were collected by filtration and washed with water and diethyl ether in turn to give the same captioned compound (1.3 g.). Total yield (2.65 g.). mp>230° C.

Provenance & Evidence