Sodium Hydroxide → HCID 23706988, compound

Participants

Reaction Steps

A mixture of 2-oxo-5-(2-chlorophenoxy)indoline (3.2 g.), sodium hydroxide (2 g.), dioxane (20 ml.) and water (40 ml.) was refluxed under heating for 5 days with stirring. After cooling, the reaction mixture was filtered. The filtrate was evaporated under reduced pressure. The residue was dissolved in ethyl acetate under warming and filtered. The filtrate was cooled in an ice bath and the precipitating crystals were collected by filtration, washed with ethyl acetate and then recrystallized from a mixture of methanol and ethyl acetate to give the captioned compound (3.2 g.). mp 105° to 115° C.

Provenance & Evidence