反应详情

A mixture of 2-oxo-5-chloro-7-(2-chlorophenoxy)indoline (2.0 g.), sodium hydroxide (0.50 g.), dioxane (20 ml.) and water (30 ml.) was refluxed under heating for 23 hours. The reaction mixture was evaporated under reduced pressure and the residue was dissolved in water and filtered. The filtrate was washed with diethyl ether, and diethyl ether was added to the aqueous layer and adjusted to pH 5 with 1N-sulfuric acid. The diethyl ether layer was separated, washed with water, dried over magnesium sulfate and then evaporated. The residue was recrystallized from ethanol to give crystals of 2-[2-amino-3-(2-chlorophenoxy)-5-chlorophenyl]acetic acid (0.725 g.).

1. temperaturewas refluxed
2. temperatureunder heating for 23 hours
3. customThe reaction mixture was evaporated under reduced pressure
4. dissolutionthe residue was dissolved in water
5. filtrationfiltered
6. washThe filtrate was washed with diethyl ether, and diethyl ether
7. additionwas added to the aqueous layer and adjusted to pH 5 with 1N-sulfuric acid
8. customThe diethyl ether layer was separated
9. washwashed with water
10. dry with materialdried over magnesium sulfate
11. customevaporated
12. customThe residue was recrystallized from ethanol