Sodium Hydroxide → HCID 23706960, compound

Participants

Reaction Steps

A mixture of 2-oxo-7-(2-chlorophenylsulfinyl)indoline (5.0 g.), dioxane (30 ml.), sodium hydroxide (2.5 g.) and water (30 ml.) was refluxed for 8 hours with stirring. The reaction mixture was evaporated under reduced pressure, and the residue was dissolved in water under heating and filtered. The filtrate was adjusted to about pH 4 with 5% sulfuric acid and extracted with diethyl ether. The extract was washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and evaporated under reduced pressure. The residue was dissolved in 1N sodium hydroxide (14.2 ml.) under heating and the solution was evaporated to dryness under reduced pressure. The oily residue was dissolved in ethanol (20 ml.) and crystallized with diethyl ether to give crystals of the captioned compound (2.9 g.). mp 248° to 251° C. (dec.).

Provenance & Evidence