反应详情

A solution of mesyl chloride (0.95 g) in pyridine (3 ml) was added to a solution of ethyl 2-[2-amino-3-(2-chlorophenoxy)phenyl]acetate (2.3 g) in pyridine (10 ml), and the mixture was stirred for an hour. The reaction mixture was poured into water (100 ml) and extracted with diethyl ether (80 ml×2). The extract was washed with 5% hydrochloric acid (50 ml×2) and saline, dried over magnesium sulfate and then evaporated in vacuo. The oily residue (2.5 g) was crystallized by treating with ethanol and the resultant solid substance was recrystallized from ethanol to give ethyl 2-[2-mesylamino-3-(2-chlorophenoxy)phenyl]acetate (0.7 g). mp 145°-149° C.

1. extractionextracted with diethyl ether (80 ml×2)
2. washThe extract was washed with 5% hydrochloric acid (50 ml×2) and saline
3. dry with materialdried over magnesium sulfate
4. customevaporated in vacuo
5. customThe oily residue (2.5 g) was crystallized
6. additionby treating with ethanol
7. customthe resultant solid substance was recrystallized from ethanol