Sodium Hydroxide → HCID 23706987, compound

Participants

Reaction Steps

A mixture of 2-oxo-7-(4-chlorophenylsulfinyl)indoline (4.7 g) and dioxane (30 ml) was added to a solution of sodium hydroxide (2.5 g) in water (30 ml), and the mixture was refluxed with stirring for 15 hrs. Dioxane was distilled off from the reaction mixture in vacuo, and the residue was dissolved in water and washed with diethyl ether. The aqueous solution was adjusted to pH 7 with 5% sulfuric acid and extracted with ethyl acetate (200 ml×2). The extract was washed with saline, dried over magnesium sulfate and then evaporated in vacuo. The residue was dissolved in 1N-sodium hydroxide (12.2 ml) under heating and the solution was concentrated in vacuo. The residue was recrystallized from ethanol twice to give powdery sodium 2-[2-amino-3-(4-chlorophenylsulfinyl)phenyl]acetate (1.5 g). mp 242°-245° C. (dec.).

Provenance & Evidence